Thymosin Alpha-1 5mg

Description

Thymosin Alpha-1 was not discovered, exactly. It was isolated. Goldstein’s laboratory pulled it out of calf thymus in 1977 as part of the thymosin fraction 5 complex and showed it was a 28-amino-acid peptide with an acetylated N-terminus. The acetyl group matters. Without it, TLR9 binding collapses and the compound you thought you were working with behaves like something else.

Proposed Mechanism

The immunology work centers on Toll-like receptor 9 and TLR2 signaling on dendritic cells. Romani et al. (2004) reported that Thymosin Alpha-1 shifts Th1/Th2 balance toward Th1 and enhances dendritic cell function in mouse models. The peptide is downstream of prothymosin alpha, and its activity profile is distinct enough from other thymosin fractions that the research literature generally handles it separately rather than as part of the broader thymosin family.

Research Literature

Goldstein et al. (1977) is the original isolation. Romani and colleagues returned to the TLR9 pathway across 2004 and 2007 papers that together form the core mechanism story. Costantini et al. (2019) reviewed the preclinical immunology literature across viral, fungal, and oncology models. Garaci et al. (2012, Annals NYAS) extended that review to 35 years of accumulated research. The compound is approved for clinical use in some jurisdictions under the trade name zadaxin, but Peptigo supplies the peptide strictly for in vitro research purposes — the clinical-use reference is context, not a recommendation.

Further reading: PubMed references for this compound.

Research Applications

Used in T-cell differentiation research, dendritic cell TLR9 signaling studies, innate immunity models, and Th1/Th2 balance assays. Frequently studied in antiviral and antifungal research contexts.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.