Semax 10mg

Description

Semax shares a family resemblance with Selank — same Pro-Gly-Pro C-terminal stabilizer, same Russian laboratory of origin — but the parent peptide is different and the pharmacology is different. Semax is ACTH(4-7) with the PGP tail attached. Crucially for anyone reading the literature: despite being derived from ACTH, it does not bind melanocortin receptors. The behavioural research is neurotropic, not steroidogenic.

Proposed Mechanism

The working mechanism is BDNF upregulation and cholinergic modulation. Dolotov et al. (2006) reported increased BDNF mRNA in rat hippocampal tissue after Semax administration. Shadrina et al. (2001) examined transcriptional changes in a cerebral ischemia rat model and documented broader gene-expression shifts consistent with a neurotropic profile. The PGP extension gives the peptide roughly 20-fold greater metabolic stability than unmodified ACTH(4-7), which is what makes in vivo rodent work practical.

Research Literature

Shadrina et al. (2001) is the transcriptional paper; Dolotov et al. (2006) is the BDNF paper; Inozemtseva et al. (2008) covered anxiolytic-like and memory-related paradigms. English-language reviews are limited — Medvedev (2017) is the accessible one and focuses on metabolic stability. Ashmarin et al. (2005, Neuroscience and Behavioral Physiology) is the most thorough review of the Russian-language base and remains the best single entry point for English-reading researchers.

Further reading: PubMed references for this compound.

Research Applications

Used in BDNF expression research, cerebral ischemia models, cognitive paradigm behavioural studies, and ACTH-receptor-independent neurotropic assays. The ACTH(4-7) backbone lacks steroidogenic activity.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.

Frequently Asked Questions

What is Semax?

Semax is a Russian-developed synthetic peptide derived from a fragment of the ACTH hormone. In research it is studied for neurological and cognitive pathways in laboratory models, and is frequently discussed alongside its relative Selank.

Semax vs Selank, what’s the difference?

Both are research peptides studied for neurological pathways, but they derive from different parent molecules and are investigated for overlapping but distinct effects. Researchers often study the pair together.

Is Semax legal in Canada?

Semax is a research-use-only material in Canada, not approved for human use. See are peptides legal in 2026.

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