Ipamorelin 5mg

Description

Ipamorelin is the selective one. Earlier GH secretagogues had a problem: they activated GH release but also elevated ACTH, cortisol, and prolactin, which made the cleanest pharmacology experiments impossible. Raun et al. (1998) at Novo Nordisk designed a pentapeptide around three non-natural amino acids (Aib, D-2-Nal, D-Phe) that bound GHSR-1a tightly and did not move any of the other pituitary axes measurably. That selectivity is the whole point of the compound.

Proposed Mechanism

Receptor target is GHSR-1a — the ghrelin receptor — expressed on pituitary somatotropes. Signaling runs through Gq-phospholipase C, which is the pathway-level distinction from GHRH receptor agonists like Mod-GRF 1-29 (Gs-coupled). Researchers often co-administer ipamorelin with a GHRH analogue specifically to examine dual-pathway somatotropic axis stimulation, where the two compounds activate complementary intracellular cascades. Raun et al. (1998) is the selectivity characterization; Andersen et al. (2001) worked out the Gq coupling details.

Research Literature

Raun et al. (1998, European Journal of Endocrinology) is the discovery paper. Gobburu et al. (1999) characterized pharmacokinetic and dose-response data. Andersen et al. (2001) worked out the Gq-coupled signaling pathway. The D-2-Nal and D-Phe residues at positions 3 and 4 carry the selectivity — replacing either with L-isomers drops receptor affinity sharply in comparable binding assays, which is a useful structural fact for anyone trying to understand why ipamorelin’s profile is different from earlier ghrelin mimetics.

Further reading: PubMed references for this compound.

Research Applications

Used in GHSR-1a selective agonist research, ghrelin-mimetic signaling studies, and dual-pathway GH-release protocols alongside GHRH analogues. The pentapeptide’s GHSR-1a selectivity makes it a reference compound for studies isolating ghrelin-axis signaling from cortisol/ACTH/prolactin pathways.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.