CJC-1295 with DAC 2mg

Description

CJC-1295 with DAC is the same 29-residue GHRH analogue as Mod-GRF 1-29, extended by a covalent linker that latches onto circulating albumin in vivo. That one modification turns a thirty-minute peptide into an eight-day one. The research question shifts accordingly — from pulsatile-response kinetics to sustained-exposure pharmacology.

Proposed Mechanism

Receptor binding is the same as the No-DAC form: GHRH receptor on pituitary somatotropes, Gs-adenylyl cyclase-PKA signaling. The difference is purely kinetic. The maleimidopropionic acid linker binds Cys34 of serum albumin through a Michael addition. That tethers the peptide to a carrier protein too large to clear quickly, producing days of functional half-life instead of minutes. Teichman et al. (2006) reported mean plasma half-life around eight days in human pharmacokinetic work. The consequence in research settings: baseline GH and IGF-1 elevation becomes tonic rather than episodic.

Research Literature

Teichman et al. (2006, J Clin Endocrinol Metab) is the pivotal paper. Jette et al. (2005) characterized the DAC linker chemistry in more detail, including the albumin-Cys34 mechanism. ConjuChem Biotechnologies developed the technology. The research literature handles the DAC and No-DAC forms as effectively different tools for different questions, which is why protocol design usually specifies one or the other rather than assuming interchangeability.

Further reading: PubMed references for this compound.

Research Applications

Used in sustained-GH-elevation pharmacology research, long-acting GPCR agonist kinetics studies, and albumin-binding drug design research. The DAC linker strategy is a reference method for peptide half-life extension.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.