HCG 5000IU

Description

Human chorionic gonadotropin is one of the oldest peptide hormones in endocrine research and one of the strangest. It is a heterodimer — two non-covalently associated subunits — and one of those subunits is shared with LH, FSH, and TSH. The receptor-specificity work all happens at the beta subunit, particularly the C-terminal 30-residue extension that distinguishes HCG from LH despite their otherwise similar structures.

Proposed Mechanism

Target: LHCGR, the luteinizing hormone/chorionic gonadotropin receptor on gonadal tissue. In Leydig cells, receptor activation drives the Gs-adenylyl cyclase-PKA cascade and upregulates steroidogenic acute regulatory protein expression, which gates testosterone biosynthesis. Lei and Rao (1992) characterized receptor distribution and signaling kinetics. The alpha subunit provides structural scaffolding; the beta subunit (and specifically the CTP extension) determines everything that matters for receptor selectivity.

Research Literature

Pierce and Parsons (1981) is the foundational structural paper on heterodimeric glycoprotein hormones. Lei and Rao (1992) covers receptor signaling. Cole (2010, Reproductive Biology and Endocrinology) is the most useful review for anyone working with research material — it covers hyperglycosylated variants, free-beta-subunit forms, and the distinctions that matter when sourcing recombinant versus pregnancy-derived HCG. Peptigo supplies this compound strictly for in vitro research purposes.

Further reading: PubMed references for this compound.

Research Applications

Used in LHCGR receptor binding studies, Leydig cell steroidogenesis research, StAR protein expression assays, and heterodimeric glycoprotein hormone structural studies. One of the most extensively characterized peptide hormones in endocrinology.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.