Epitalon 10mg

Description

Epitalon is four amino acids — Ala-Glu-Asp-Gly — and one of the more unusual research compounds in the peptide literature. It was developed from epithalamin, a peptide fraction that Morozov and Khavinson isolated from bovine pineal gland in the 1970s. The Russian geroscience research around it is extensive; the mechanistic question of how exactly it works is still open.

Proposed Mechanism

The working model is not classical receptor binding. Khavinson and colleagues have reported effects on telomerase expression in aging-related cell models and on circadian rhythm markers in aged rodents. The current proposal is that the tetrapeptide acts through transcriptional and epigenetic modulation rather than through a specific cell-surface or nuclear receptor. That is a softer mechanism story than most compounds in this catalog, and the research literature is explicit about it.

Research Literature

Khavinson et al. (2003, Biogerontology) reported telomerase-activity findings in fibroblast cultures. Anisimov et al. (2003) examined aged murine models. Anisimov and Khavinson (2010, Biogerontology) reviewed 30 years of Epitalon research, including the circadian-marker work in aged rodents. The bulk of the primary literature is Russian-language; Khavinson’s laboratory publications in English are the accessible path in for researchers outside that tradition.

Further reading: PubMed references for this compound.

Research Applications

Used in telomerase-activity research, fibroblast senescence assays, circadian-rhythm gene expression studies, and pineal-peptide biology research. The receptor target remains under active investigation.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.

Frequently Asked Questions

What is Epitalon?

Epitalon is a synthetic tetrapeptide from the Soviet-era peptide bioregulator research (the Khavinson tradition). In research it is studied for pineal-gland-related and telomere-related pathways, though the human evidence is limited.

What is Epitalon studied for in research?

Researchers investigate Epitalon for its reported effects on telomerase activity and circadian and sleep-related processes in laboratory and animal models. We touch on the bioregulator research in our Huberman peptide episode recap.

Is Epitalon legal in Canada?

Epitalon is sold strictly as a research material in Canada and is not approved for human use. See are peptides legal in 2026.

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