Tesamorelin 10mg

Description

Tesamorelin is a 44-residue GHRH analogue — the full-length hGRF(1-44) sequence with an N-terminal trans-3-hexenoic acid modification. The hexenoyl group blocks the same enzymatic cleavage that destroys native GHRH, but it reaches the problem from a different chemical angle than the D-Ala2 substitution used in short-fragment analogues like Mod-GRF 1-29. The research interest in tesamorelin is largely about what a full-length stabilized GHRH analogue does that a truncated one does not.

Proposed Mechanism

Receptor binding at the GHRH receptor on pituitary somatotropes, Gs-adenylyl cyclase-PKA signaling — the canonical GHRH cascade. What distinguishes tesamorelin from the 1-29 fragment analogues is that the retained C-terminal residues contribute to receptor binding kinetics in ways the truncated form cannot replicate. Ferdinandi et al. (2007) is the pharmacokinetic characterization that anchors the research base. The N-terminal hexenoyl modification is analogous in effect to D-Ala2 — both confer DPP-IV resistance — but the chemistry is distinct.

Research Literature

Ferdinandi et al. (2007, Basic & Clinical Pharmacology & Toxicology) is the pivotal pharmacokinetic paper. Falutz et al. (2007, NEJM) examined the compound in clinical pharmacology research. Stanley et al. (2011) extended that work with longer-duration pharmacology data. The full-length class is distinguished from the 1-29 fragment class in the research literature by its retained native sequence, which makes tesamorelin a reference compound for protocols that need GHRH-receptor kinetics closer to endogenous signaling.

Further reading: PubMed references for this compound.

Research Applications

Used in full-length GHRH receptor binding studies, pulsatile GH-release pharmacology research, and hexenoyl-modification peptide stability studies. Differs from shorter GHRH fragment analogues through its retained 44-residue native sequence.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.