SLU-PP-332 10mg

Description

SLU-PP-332 is not a peptide. It is a small-molecule pan-agonist of the estrogen-related receptors — ERRalpha, ERRbeta, ERRgamma — a family of orphan nuclear receptors that regulate mitochondrial biogenesis. The receptor family has historically lacked good tool compounds, which is the specific problem SLU-PP-332 was built to solve. If you are running mitochondrial biogenesis research, this is one of the few selective tools available.

Proposed Mechanism

The ERR family regulates transcription of PGC-1alpha, NRF1, and TFAM — the core mitochondrial biogenesis program. SLU-PP-332 activates this transcriptional network through the nuclear receptors directly, which makes its mechanism distinct from classical estrogen receptor signaling despite the name resemblance. Billon et al. (2023, Journal of Medicinal Chemistry) published the discovery and pharmacology. Xu et al. (2024) characterized the mitochondrial gene expression changes downstream.

Research Literature

Billon et al. (2023) is the discovery paper. Billon et al. (2024, Science Translational Medicine) extended the characterization with skeletal muscle bioenergetics data. Huss et al. (2015) reviewed the broader ERR signaling network for researchers who need the background before approaching SLU-PP-332 specifically. Because the ERR family is small and historically under-tooled, new selective ligands get a disproportionate amount of attention in the mitochondrial research literature.

Further reading: PubMed references for this compound.

Research Applications

Used in ERR pan-agonist pharmacology research, mitochondrial biogenesis transcriptional studies, PGC-1alpha/NRF1/TFAM expression assays, and skeletal muscle oxidative-metabolism research.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.