CJC-1295 10mg

Description

The compound researchers tend to call CJC-1295 No DAC is more precisely known as Mod-GRF 1-29 — a 29-residue GHRH analogue with four substitutions that block the enzymatic cleavage that destroys native GHRH within minutes. If you are designing a protocol that needs pulsatile GH response rather than sustained elevation, this is the variant to reach for.

Proposed Mechanism

The compound binds the GHRH receptor on anterior pituitary somatotropes and triggers the canonical Gs-adenylyl cyclase-PKA cascade. The four substitutions (D-Ala2, Gln8, Ala15, Leu27) confer resistance to dipeptidyl peptidase IV. Without them, native GHRH is cleaved between residues 2 and 3 within two to five minutes; with them, the half-life extends to roughly thirty. That thirty-minute window is what makes pulsatile GH work tractable in rodent and cell research.

Research Literature

The four-residue stabilization pattern traces back to Campbell et al. (1994) in the broader GHRH analogue literature. Teichman et al. (2006) published the pharmacokinetic characterization that anchors the modern research base. Sackmann-Sala et al. (2015) reviewed the GHRH analogue class, placing Mod-GRF 1-29 alongside sermorelin and other short-acting variants. The No-DAC designation matters: it distinguishes this compound from the albumin-binding DAC-conjugated form, which runs closer to an eight-day half-life and produces sustained GH elevation rather than pulses.

Further reading: PubMed references for this compound.

Research Applications

Used in GHRH receptor binding studies, pulsatile GH-release pharmacology research, and co-administration protocols with GHSR-1a agonists such as Ipamorelin. The short half-life produces physiological GH pulses rather than sustained elevation.

Supplied strictly for laboratory research use. Not for human or veterinary use.

Reconstitution

Supplied as a lyophilized powder. Reconstitute with bacteriostatic water prior to use. Use the Peptigo reconstitution calculator for guidance on volume and concentration.

Storage

• Unopened: room temperature up to 30 days during transit; refrigerate at 2-8°C long-term.
• Reconstituted: refrigerate at 2-8°C; stable 4-6 weeks. Protect from light.

Quality Verification

Every batch is independently tested by Janoshik Analytical. Certificates of Analysis include HPLC-UV purity, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP <71> sterility testing.

Not a drug, supplement, or cosmetic. For in vitro research use only. Not for human consumption.

Frequently Asked Questions

Is this product legal to purchase in Canada for research use?

Peptigo supplies all products strictly for laboratory and in vitro research use. The compound is not a drug, supplement, or cosmetic, and is not sold for human or veterinary use. Researchers purchasing for their own laboratory work, university research programs, or independent in vitro protocols are the intended customer base. Health Canada’s April 2026 advisory specifically addresses unauthorized injectable peptide use; the research-use framing of this product is independent of that consumer-use category.

How is purity verified, and where can I see the Certificate of Analysis?

Every batch is tested independently by Janoshik Analytical, an accredited third-party laboratory. The standard testing panel includes HPLC-UV purity verification, LC-MS identity confirmation, LAL bacterial endotoxin quantification, and USP sterility testing. The Certificate of Analysis for each batch is available on the product page after purchase, and the testing methodology is detailed on the Lab Testing reference page.

What is the standard reconstitution and storage protocol for laboratory use?

The compound is supplied as a lyophilized powder. The standard diluent for reconstitution in research protocols is bacteriostatic water (0.9% benzyl alcohol). The Peptigo reconstitution calculator handles the volume-and-concentration arithmetic for a given target research dose. Unopened lyophilized peptide is stable at room temperature for up to 30 days during transit and should be refrigerated at 2-8°C for long-term storage. Reconstituted peptide should be refrigerated at 2-8°C and is typically functional for 4-6 weeks; protect from light.

Frequently Asked Questions

What is CJC-1295 (no DAC)?

CJC-1295 without DAC is a synthetic peptide studied as a growth-hormone-releasing hormone (GHRH) analog. In research it is used to investigate short, controlled pulses of growth-hormone release, which is why it is often studied alongside a ghrelin-mimetic like ipamorelin.

CJC-1295 vs CJC-1295 with DAC, what’s the difference in research?

The “no DAC” form clears the body in a few hours and is studied for sharp, pulsatile GH-release patterns. The DAC version carries an added molecule that extends its presence for days, so researchers study it for a more sustained baseline. See our peptides for muscle growth guide for the full GHRH/GHRP picture.

Is CJC-1295 legal to buy in Canada?

In Canada, peptides like CJC-1295 are unapproved drugs sold strictly as research materials, not for human use. We cover the regulatory picture in detail in are peptides legal in 2026.

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